Preclot 75mg Tablet 10pcs

Uses of Preclot 75mg Tablet

• Prevention of Heart Attack and Stroke
• Peripheral Vascular Disease

How does Preclot 75mg Tablet work?

Preclot 75 is an antiplatelet medication that prevents platelets in the blood from sticking together. This reduces the formation of harmful blood clots, thereby lowering the risk of a heart attack or stroke.

Side Effects of Preclot 75mg Tablet

Abdominal pain, Bruise, Diarrhea, Hematoma, Nosebleeds, Gastrointestinal bleeding, Dyspepsia

Quick Suggestions:

• For optimal results, take Preclot 75 at the same time every day.
• Be cautious to avoid injuries or cuts, as Preclot 75 increases the risk of bleeding.
• Do not stop taking Preclot 75 without consulting your doctor, as stopping it suddenly may increase your risk of another heart attack or stroke.
• Inform your doctor or dentist that you are taking Preclot 75 if you are scheduled for surgery or dental work, as you might need to temporarily stop the medication.

Indication of Preclot 75mg Tablet

• Prevent blood clots (thrombi) forming in hardened blood vessels (atherothrombosis)
• Manage atherosclerotic events (myocardial infarction)
• Prevent in-stent restenosis in patients undergoing percutaneous coronary intervention (PCI)

Pharmacology

Clopidogrel is a prodrug. It inhibits platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y12 class of ADP receptors on platelets. Dose-dependent inhibition of platelet aggregation can be seen 2 hours after single oral doses. Repeated doses of 75 mg per day inhibit ADP-induced platelet aggregation on the first day, and inhibition reaches a steady state between Day 3 and Day 7.

Adult Dose for Preclot 75:

Oral Prophylaxis of Thromboembolic Disorders, Recent MI, Stroke, or Established Peripheral Arterial Disease, Coronary Artery Disease:

• Adult: 75 mg once daily.

Acute Coronary Syndrome (ACS):

ST-Elevation Myocardial Infarction (STEMI):

• Adults under 75 years: 300 mg loading dose followed by 75 mg once daily, typically for 14 days up to 12 months, if there is no significant bleeding.
• Concomitant Therapy: Administer in combination with aspirin 75-325 mg once daily, with or without thrombolytics.
• Adults 75 years and older: No loading dose; just 75 mg once daily for 14 days up to 12 months, depending on the risk of bleeding.

Unstable Angina (UA) or Non-ST-Elevation Myocardial Infarction (NSTEMI):

• Adult: Initially, a 300 mg loading dose followed by 75 mg once daily for up to 12 months. This should be combined with aspirin.

Hepatic Impairment:

• Use with caution due to limited experience in this population.

Renal Dose:

• Renal Impairment:
  • Dose adjustment is not necessary.

Children

Clopidogrel is not recommended for children.

Administration of Preclot 75mg Tablet

• Take Preclot 75 exactly as prescribed by your doctor.
• Swallow the tablet whole; do not chew, crush, or break it.
• It can be taken with or without food, but try to take it at the same time every day for consistency.

Interaction

Drug-Drug Interactions:

• Blood Thinners: Combining with other anticoagulants like warfarin or heparin increases the risk of bleeding.
• Anti-Psychotics: Interaction with drugs like fluoxetine or lithium can enhance the risk of bleeding.
• Anti-Diabetics: Drugs like glibenclamide or repaglinide may interact and increase the risk of hypoglycemia.
• Anti-Cancer Drugs: Methotrexate may have enhanced toxicity when used with Preclot 75.
• Gout Medications: Probenecid interaction can increase the risk of adverse effects.
• Anti-Epilepsy Drugs: Medications like valproate or phenytoin may have increased blood levels and toxicity.
• Anti-Inflammatory Drugs: Ibuprofen and other NSAIDs can increase the risk of gastrointestinal bleeding.
• Stomach Upset Medications: Omeprazole can reduce the effectiveness of clopidogrel.
• Antifungals: Fluconazole can inhibit clopidogrel metabolism.
• HIV Drugs: Ritonavir and cobicistat may reduce the effectiveness of clopidogrel.

Drug-Food Interaction: Limit alcohol intake as it can raise blood pressure and increase the risk of heart disease. Also, avoid fatty foods and maintain a healthy diet to control cholesterol and triglyceride levels.

Drug-Disease Interaction: Inform your doctor if you have a history of allergic reactions, heart disease, active bleeding disorders, asthma, ischaemic stroke, liver, or kidney disease, as these conditions can increase the risk of side effects or alter the effectiveness of Preclot 75.

Contraindications

• Contraindicated in patients with known hypersensitivity to clopidogrel or any component of the product.
• Contraindicated in conditions such as peptic ulcer or intracranial hemorrhage.
• Contraindicated when administered within 7 days after myocardial infarction (MI) or ischemic stroke.
• Use with caution due to bleeding risks.
• Contraindicated during breastfeeding.

Pregnancy & Lactation

Preclot 75 is not recommended for breastfeeding mothers since the drugs can pass into breast milk and potentially harm the nursing infant. Discuss alternative treatments with your doctor if you are breastfeeding.

Precautions & Warnings

• Do not take Preclot 75 if you are allergic to either aspirin or clopidogrel. Allergic reactions can be severe and may include symptoms like rash, itching, swelling, dizziness, or trouble breathing.
• Avoid this medication if you have a condition that increases your risk of bleeding, such as hemophilia, active stomach ulcers, or bleeding within the brain or bowel. Preclot 75 can increase the risk of bleeding, which may be life-threatening.
• Caution is advised when prescribing Preclot 75L to patients with liver or kidney issues, as these conditions may exacerbate potential side effects or alter the drug's effectiveness.
• Individuals with respiratory conditions like asthma, rhinitis, or nasal polyps should consult a doctor before taking Preclot 75, as aspirin can exacerbate these conditions.
• The safety and effectiveness of Preclot 75 in children under 12 years of age have not been established. It is generally not recommended for use in this age group.

Storage:

• Keep the medicine out of reach in children
• Store Preclot 75 at room temperature